Metabolism and Epigenetics

General Scheme of Central Metabolism and Epigenetics. Excess of nutrients "feeding" the mitochondria (such as glucose or fatty acids), will lead to a increase in citrate output, and then in Acetyl-CoA (in the cytosol/nucleus). Alternatively, acetate treatment could by-pass this process but still rendering a similar output. Acetyl-CoA is a key substrate for protein acetylation.

Research questions: We are what we eat?

  • To which extension nutrition affects the way our genes are expressed?
  • How is this associated with pathology?
  • Can a disease condition be reverted by a simple modulation of nutrients and/or its metabolism?