General Scheme of Central Metabolism and Epigenetics. Excess of nutrients "feeding" the mitochondria (such as glucose or fatty acids), will lead to a increase in citrate output, and then in Acetyl-CoA (in the cytosol/nucleus). Alternatively, acetate treatment could by-pass this process but still rendering a similar output. Acetyl-CoA is a key substrate for protein acetylation.
Research questions: We are what we eat?