Dr Colombo's current research interests are focused on the: 1) the mitochondrial role in the pathophysiology of diabetes, 2) the regulation of the central metabolism during cell cycle progression, and 3) the role of metabolism on the epigenetics of normal and pathological cells (including cancer).
Opportunities to carry out postgraduate research towards an MPhil / PhD exist in the School of Science and Technology and further information may be obtained from the NTU Graduate School.
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General Scheme of Central Metabolism and Epigenetics
Excess of nutrients feeding the mitochondria, such as glucose or fatty acids, leads to a increase in citrate output, increasing the pool of Acetyl-CoA in the cytosol/nucleus. Similarly, acetate treatment renders a similar output. Whatever the case, this pool of Acetyl-CoA induces global protein acetylation, including histone acetylation, and then, altered gene expression and protein function.
My favourite molecular tool!
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